Guillaume ARCILE

• Extraction (ASE, Zippertex) and purification technologies (Flash chromatography, preparative HPLC)
• Analytical/Structural chemistry (MS,NMR) Biocatalysis
• Organic synthesis

1. RABHI C., CARIEL L., OUAZZANI J., ARCILE G. Process for the production of a specific extract and related formulations, against DMLA disorder. French Patent reference 1355652, 2013 CNRS/Ethnodyne.

2. RABHI C, CARIEL L, OUAZZANI J, ARCILE G, Use of a withania extract for the treatment of alpha synucleinopathies. 2015, PCT/FR2015/050985

3. RABHI C, CARIEL L, OUAZZANI J, ARCILE G, Use of a withania extract for the treatment of amyloidrelated diseases. 2015, PCT/EP2015/056132

4. RABHI C, CARIEL L, OUAZZANI J, ARCILE G, Method for producing a plant extract and associated compositions. 2015, WO 2014/202469 A1.

5. Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001757, 2017.

6. Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001758, 2017.

7. Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001759, 2017.

8. Chérif RABHI, Jamal OUAZZANI, Guillaume ARCILE,. USE OF A WITHANIA EXTRACT FOR THE TREATMENT OF NEUROMUSCULAR DISEASES, ETHNODYNE/CNRS, WO/2017/178856, 2017.

LE GOFF G., ADELIN E., ARCILE G., OUAZZANI J. Total synthesis of the antibiotic 4-hydroxycyclopent-2-en-1-one acrylate derivative EA-2801. Tetrahedron Letters, 2017, 58, 2337–2339.

RABHI C., ARCILE G., CARIEL L., LENOIR C., BIGNON J., WDZIECZAK-BAKALA J., OUAZZANI J. Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants . J. Med. Food. 2015, doi:10.1089/jmf.2014.0128.

MARTINS M.P, OUAZZANI J., ARCILE G., JELLER A.H., DE LIMA J.P.F., SELEGHIM M.H.R., OLIVEIRA A.L.L., DEBONSI H.M., VENÂNCIO T., YOKOYA N.S., FUJII M.T., PORTO A.L.M. Biohydroxylation of (−)-Ambrox®, (−)-Sclareol, and (+)- Sclareolide by Whole Cells of Brazilian Marine-Derived Fungi. Marine Biotechnology 2015. doi:10.1007/s10126-015-9610-7.

ADELIN E., SERVY C., MARTIN M-T., ARCILE G., IORGA B.I., RETAILLEAU P., BONFILL M., OUAZZANI J. Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata. Phytochemistry, 2014, 97, 55-61.