THE PILOT UNIT OF ICSN - EXCELLENCE IN THE FIELD OF BIOACTIVE MICROBIAL SECONDARY METABOLITES
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Géraldine LE GOFF

geraldine.legoff@cnrs.fr
+33.1.69.82.30.05

Researcher engineer

Lecturer

 

Current position
Research Engineer CNRS, ICSN, Paris (France)
Lecturer in Biotechnology, Mines Paris-Tech, Paris, (France)

Running projects
• EU Projects: H2020 TASCMAR
• National Projects : ANR MiGenIs, ANR HerbiFun
• Industrial: Ethnodyne
• Academic Projetcs: various worldwide collaborations (Spain, Germany, UK, Greece, Brazil, Thailand, Morrocco …)

Previous projects
• EU Projects: MICROSMETICS

Previous work experience
Post-doctoral fellowship CNRS, ICSN – 2012-2016

Education
• PhD in Microbiology and Medicinal Chemistry, Museum National d’Histoire Naturellle (MNHN), France, 2012
• Master (Natural Resources Valorisation), Université de La Réunion, 2009

Fields of expertise

Dr. Géraldine LE GOFF is a CNRS research engineer at Natural Product Chemistry Institute, ICSN (www.icsn.cnrs-gif.fr). ICSN benefit from a worldwide-recognition in the chemistry of natural compounds, including isolation, structure elucidation, bioassays and industrial valorization, from various natural bio resources (plants, marine organisms, microorganisms).

She is a specialist in Bioactive Microbial Secondary Metabolites. The Pilot-Unit is a unique R&D structure in CNRS, equipped with up-to-date pilot scale facilities in the fields of fermentation, extraction and purification of small molecules and proteins. This structure is dedicated to the discovery of drugs from microorganisms. She develops new cultivation supports and metabolite trapping strategies and technologies. The team is now considered as a reference in the field of solid-state cultivation and solid-phase extraction. Unique pilot-scale innovative instruments were invented and built offering an exceptional support for the discovery of new families and scaffolds of natural compounds (Platotex,Unifertex, Zippertex, Somartex). She is specialist in natural products structural elucidation (Geralcins family, Sporochartine family, Crambescins and crambescidins family). In partnership with indisputable experts, she initiated the total syntheses and the investigation of the biosynthetic gene clusters of particular families of natural compounds from actinomycetes (Geralcins).

Publications

1- P. Vlachou, G. Le Goff, C. Alonso, P. A. Álvarez , J-F. Gallard, Nikolas Fokialakis and Jamal Ouazzani; Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems. Mar. Drugs, 2018, 16, 0152. https://doi.org/10.3390/md16050152

2 - C. Leman-Loubière, G. Le Goff, C. Debitus and J. Ouazzani ; Sporochartines A–E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge; Frontiers in Marine Science, 2017, 4, 399. https://doi.org/10.3389/fmars.2017.00399

3 - C. Leman-Loubière, G. Le Goff, P. Retailleau, Cécile Debitus, and Jamal Ouazzani; Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast; J. Nat. Prod. 2017. https://doi.org/10.1021/acs.jnatprod.7b00714

4 - G. Le Goff, E. Adelin, G. Arcile and J. Ouazzani; Total synthesis of the antibiotic 4-hydroxycyclopent-2-en-1-one acrylate derivative EA-2801;Tetrahedron Letters, 2017, 58, 2337. https://doi.org/10.1016/j.tetlet.2017.04.086

5 - E. Adelin, G. Le Goff, P. Retailleau, M. Bonfill and J. Ouazzani; Isolation of the antibiotic methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate EA-2801 from Trichoderma atroviridae; The Journal of Antibiotics, 2017, 00, 1–4. https://doi.org/10.1038/ja.2017.107

6 A. Vingadassalon, F. Lorieux, M. Juguet, G. Le Goff, C. Gerbaud, J.L. Pernodet, and S. Lautru ; Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis. ACS Chem. Biol., 2015, 10 (2), 601. https://doi.org/10.1021/cb500652n

7 G. Le Goff, J. Ouazzani ; Natural hydrazine-containing compounds: Biosynthesis, isolation, biological activities and synthesis. BMC., 2014, 22(23),6529. https://doi.org/ 10.1016/j.bmc.2014.10.011

8 G. Le Goff, E. Roulland and J. Ouazzani; Total synthesis of geralcin A, a representative of a new family of hydrazine-containing natural products. Tet. Lett., 2013, 54(39), 5299. https://doi.org/10.1016/j.tetlet.2013.07.087

10 G. Le Goff, E. Adelin, S. Cortial, C. Servy, and J. Ouazzani; Application of solid-phase extraction to agar-supported fermentation. Bioprocess and Biosystems Ingineering, 2013, 36(9), 1285. https://doi.org/10.1007/s00449-012-0873-3

11 G. Le Goff, M.T. Martin, C. Servy, S. Cortial, I. Bogdan, E. Adelin and J. Ouazzani; Isolation and Characterization of Unusual Hydrazides from Streptomyces sp. Impact of the Cultivation Support and Extraction Procedure. J. Nat. Prod, 2013, 76(2), 142. https://doi.org/10.1021/np300527p

12 G. Le Goff, M.T. Martin, C. Servy, S. Cortial, P. Lopes, A. Bialecki, J. Smadja and J.Ouazzani; . Isolation and Characterization of α,β-Unsaturated γ-Lactono-Hydrazides from Streptomyces sp. J. Nat. Prod, 2012, 75, 915. https://doi.org/10.1021/np300026p

13 E. Adelin, C. Servy, S. Cortial, H. Levaique, M.T. Martin, P. Retailleau, G. Le Goff, B. Bussaban, S. Lumyong and J. Ouazzani; . Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA. Phytochemistry, 2011, 72, 2406. https://doi.org/10.1016/j.phytochem.2011.08.010

14 J. Smadja, D. Strasberg, G. Le Goff and A. GauvinBalecki; Volatile compounds from Melicope obscura. Chemistry and Biodiversity, 2010, 7(2), 467. https://doi.org/ 10.1002/cbdv.200900098

Patents
  • Jamal OUAZZANI, Géraldine LE GOFF. Somartex, Self Operating MARine Trapping EXtractor. CNRS, INPI 1850669, 2018
  • Jamal OUAZZANI, Géraldine LE GOFF, Doru FELEZEU, Arnaud TOURON, Christophe ALLEGRET-BOURDON, UNIFERTEX, UNIversal FERmentor EXpert, device for microbial cultivation. CNRS/Pierre Guerin Technologies, INPI 1763222, 2017
  • Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001757, 2017
  • Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001758, 2017
  • Chérif RABHI, Léon CARIEL, Christian DA COSTA NOBLE, Jamal OUAZZANI, Guillaume ARCILE, Géraldine LE GOFF. Compounds For Treating Neurodegenerative Disorders, ETHNODYNE/CNRS, PCT/IB2017/001758, 2017
  • Ouazzani, J., Adelin, E., Le Goff, G. 4-vinyl-2-cyclopenten-1-one, the production thereof, and the use of same as an antibiotic agent. WO2015/169876, PCT/EP2015/059999, 2015