THE PILOT UNIT OF ICSN - EXCELLENCE IN THE FIELD OF BIOACTIVE MICROBIAL SECONDARY METABOLITES

Recent Publications

2018

Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems. Vlachou, G. Le Goff, C. Alonso, P. A. Álvarez , J-F. Gallard, Nikolas Fokialakis and Jamal Ouazzani; Mar. Drugs, 2018, 16, 0152. doi.org/10.3390/md16050152


2017

Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge.
Leman-Loubière, C.; Le Goff, G.; Retailleau, P.; Debitus, C.; Ouazzani, J. Frontiers in Marine Biotechnology, 2017, DOI: 10.3389/fmars.2017.00399

Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast.
Leman-Loubière, C.; Le Goff, G.; Retailleau, P.; Debitus, C.; Ouazzani, J. (2017). J. Nat .Prod. http://dx.doi.org/10.1021/acs.jnatprod.7b00714 .

Viability-reducing activity of Coryllus avellana L. extracts against human cancer cell lines. GALLEGO A., METON I., BAANANTE I.V., OUAZZANI J., ADELIN E., PALAZON J., BONFILL M., MOYANOA E. Biomedicine & Pharmacotherapy 2017, 89, 565–572.

Total synthesis of the antibiotic 4-hydroxycyclopent-2-en-1-one acrylate derivative EA-2801. LE GOFF G., ADELIN E., ARCILE G., OUAZZANI J. . Tetrahedron Letters, 2017, 58, 2337–2339.

Isolation of the antibiotic methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate EA-2801 from Trichoderma atroviridae.
Emilie Adelin, Géraldine Le Goff, Pascal Retailleau, Mercedes Bonfill and Jamal Ouazzani. The Journal of Antibiotics (2017) 00, 1–4. doi:10.1038/ja.2017.107


2016

Seeking the fountain of youth in the twilight zone.
OUAZZANI J., BENAYAHU Y., TROUGAKOS I.  The Marine Biologist, 2016, 7, 9−11.


2015

Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants.
RABHI C., ARCILE G., CARIEL L., LENOIR C., BIGNON J., WDZIECZAK-BAKALA J., OUAZZANI J. Journal of Medicinal .
J. Med. Food. 2015, doi:10.1089/jmf.2014.0128.

Biohydroxylation of (−)-Ambrox®, (−)-Sclareol, and (+)- Sclareolide by Whole Cells of Brazilian Marine-Derived Fungi.
Mariana P. Martins, Jamal Ouazzani, Guillaume Arcile, Alex H. Jeller, João P. F. de Lima, Mirna H. R. Seleghim, Ana Lígia L. Oliveira, Hosana M. Debonsi, Tiago Venâncio, Nair S. Yokoya, Mutue T. Fujii, André L. M. Porto.
Mar Biotechnol (NY). 2015, 17(2):211-8.


2014

Natural hydrazine-containing compounds: biosynthesis, isolation, biological activities and synthesis.
Géraldine Le Goff and Jamal Ouazzani.
Bioorg Med Chem, 2014. 22, 6529–6544.

Agar-supported cultivation of Halorubrum sp. SSR, and production of halocin C8 on the scale-up prototype Platotex.
Rima Meknaci , Philippe Lopes, Claudine Servy, Jean-Pierre Le Caer, Jean-Pierre Andrieu, Hocine Hacène, Jamal Ouazzani.
Extremophiles, 2014, 18(6), 1049-1055.

Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata.
Adelin E, Servy C, Martin M-T, Arcile G, I. Iorga B, Pretailleau P, Bonfill M, Ouazzani J.
Phytochemistry, Volume 97, 2014, Pages 55–61.


2013

Total synthesis of geralcin A, a representative of a new family of hydrazine-containing natural products.
Géraldine Le Goff, Emmanuel Roulland, Jamal Ouazzani.
Tetrahedron Letters. 2013, volume 54, issue 39, Pages 5299–5301.

Application of solid-phase extraction to agar-supported fermentation.

Géraldine Le Goff, Emilie Adelin, Sylvie Cortial, Claudine Servy, Jamal Ouazzani.
Bioprocess Biosyst Eng. 2013, 36,1285–1290.

Isolation and Characterization of Unusual Hydrazides from Streptomyces sp. Impact of the Cultivation Support and Extraction Procedure.
Géraldine Le Goff, Marie-Thérèse Martin, Bogdan I. Iorga, Emilie Adelin, Claudine Servy, Sylvie Cortial, Jamal Ouazzani.
Journal of Natural Products. 2013, volume 76, issue 2,pages 142–149.
New bioactive polyketides isolated from agar-supported fermentation of Phomopsis sp. CMU-LMA, taking advantage of the scale-up device, Platotex.
Emilie Adelin, Marie-Thérèse Martin, Sylvie Cortial, Pascal Retailleau, Jamal Ouazzani.
Phytochemistry,Volume 93, 2013, Pages 170-175.


2012

Biotransformation of natural compounds: Unexpected thio conjugation of Sch-642305 with 3-mercaptolactate catalyzed by Aspergillus niger ATCC 16404 cells
Emilie Adelin, Marie-Thérèse Martin, Marie-Françoise Bricot, Sylvie Cortial, Pascal Retailleau, Saisamorn Lumyong, Jamal Ouazzani.
Phytochemistry, Volume 84, 2012, Pages 135-140.

Dehydrogenation, oxidative denitration and ring contraction of N,N-dimethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1
Sylvie Cortial, Philippe Chaignon, Didier Sergent, Sophie Dezard, Jamal Ouazzani.
Journal of Molecular Catalysis B: Enzymatic, Volume 76, 2012, Pages 1-8.

Isolation and characterization of α,β-unsaturated γ-lactono-hydrazides from Streptomyces sp.
Géraldine Le Goff, Marie-Thérèse Martin, Claudine Servy, Sylvie Cortial, Philippe Lopes, Anne Bialecki, Jacqueline Smadja, Jamal Ouazzani.
Journal of Natural Products. Volume 75, Issue 5, 2012, Pages 915-919.

Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics.
Calligari PA, Salgado GF, Pelupessy P, Lopes P, Ouazzani J, Bodenhausen G, Abergel D.
Proteins. Volume 80, Issue 4, 2012, Pages1196-1210.


2011

Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA.
Emilie Adelin, Claudine Servy, Sylvie Cortial, Hélène Lévaique, Marie-Thérèse Martin, Pascal Retailleau, Géraldine Le Goff, Boonsom Bussaban, Saisamorn Lumyong, Jamal Ouazzani.
Phytochemistry, Volume 72, Issue 18, 2011, Pages 2406-2412.

Microbial decyanation of 1-benzylpyrrolidine-2,5-dicarbonitrile. Mechanistic investigations
Lucimar Pinheiro, Didier Buisson, Sylvie Cortial, Marcel Delaforge, Jamal Ouazzani.
Journal of Molecular Catalysis B: Enzymatic, Volume 68, Issue 2, 2011, Pages 211-215

Biotransformation of natural compounds. Oxido-reduction of Sch-642305 by Aspergillus ochraceus ATCC 1009
Emilie Adelin, Claudine Servy, Sylvie Cortial, Hélène Lévaique, Jean François Gallard, Marie-Thérèse Martin, Pascal Retailleau, Boonsom Bussaban, Saisamorn Lumyong, Jamal Ouazzani.
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 8, 2011, Pages 2456-2459.

Monitoring the dynamics of monomer exchange using electrospray mass spectrometry: the case of the dimeric glucosamine-6-phosphate synthase.
Chevreux G, Atmanene C, LopeS P, Ouazzani J, Van Dorsselaer A, Badet B, Badet-Denisot MA, Sanglier-Cianférani S.
J Am Soc Mass Spectrom. Volume 22, Issue 3, 2011, Pages 431-439.

Platotex: an innovative and fully automated device for cell growth scale-up of agar-supported solid-state fermentation.
Adelin E, Slimani N, Cortial S, Schmitz-Alfonso I, Ouazzani J.
J Ind Microbiol Biotechnol. Volume 38, Issue 2, 2011, Pages 299-305.


2010

NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role.
Cortial S, Chaignon P, Iorga BI, Aymerich S, Truan G, Gueguen-Chaignon V, Meyer P, Moréra S, Ouazzani J.
FEBS Lett. Volume 584, Issue 18, 2010, Pages 3916-3922.

Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
Leverrier A, Martin MT, Servy C, Ouazzani J, Retailleau P, Awang K, Mukhtar MR, Guéritte F, Litaudon M. Journal of Natural Products. Volume 73, Issue 6, 2010, 1121-1125.