THE PILOT UNIT OF ICSN - EXCELLENCE IN THE FIELD OF BIOACTIVE MICROBIAL SECONDARY METABOLITES

Recent Publications

2020

The Sporothriolides. A New Biosynthetic Family of Fungal Secondary Metabolites.
Dong-Song Tian, Eric Kuhnert, Jamal Ouazzani, Daniel Wibberg, Jörn Kalinowskic and Russell J. Cox. Chemical Science (Submitted)

Marine Fungus Aspergillus Chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress.
Sophia Letsiou, Artemis Bakea, GĂ©raldine Le Goff, Philippe Lopes, Κonstantinos Gardikis, Michal Weis, Yehuda Banayahu and Jamal Ouazzani. Mar. Drugs Drugs 2020, 18, 460-473.

Microorganisms associated with the marine sponge Scopalina hapalia: a reservoir of bioactive molecules to slow down the aging process.
Said Hassane C.; Fouillaud M.; Le Goff G.; Sklirou A.D; Boyer J.B; Trougakos I.P.; Jerabek M.; Bignon J.; De Voogd N.J; Ouazzani J.; Gauvin-Bialecki A.; Dufossé L. Microorganisms 2020, 8, 1262-1285.

Investigating the biosynthesis of Sch-642305 in the fungus Phomopsis sp. CMU-LMA
Francesco Trenti, Karen E. Lebe, Emilie Adelin, Jamal Ouazzani, Carsten Schotte, Russell J. Cox. RSC Advances, 2020, 10, 27369-27376

Osirisynes G-I, new long-chain highly oxygenated polyacetylenes from the Mayotte Marine Sponge Haliclona sp.
Pierre-Eric CAMPOS , Gaëtan HERBETTE , Christophe Chendo , Patricia CLERC , Florent TINTILLIER , Nicole J. DE VOOGD , Eleni-Dimitra PAPANAGNOU , Ioannis P. TROUGAKOS , Moran JERABEK , JérÎme BIGNON , Géraldine LE GOFF , Jamal OUAZZANI , Anne GAUVIN-BIALECKI. Mar. Drugs 2020, 18(7), 350-369

Degradation Mechanism of 2,4-Dichlorophenol by Fungi Isolated from Marine Invertebrates
Efstratios Nikolaivits, Andreas Agrafiotis, Eirini Baira, GĂ©raldine Le Go ff, Nikolaos Tsafantakis, Suchana A. Chavanich, Yehuda Benayahu, Jamal Ouazzani,
Nikolas Fokialakis and Evangelos Topakas. Int. J. Mol. Sci. 2020, 21, 3317; doi:10.3390/ijms21093317

In vitro protective effects of marine-derived Aspergillus puulaauensis TM124-S4 extract on H2O2-stressed primary human fibroblasts
Sophia Letsiou, Artemis Bakea, Géraldine Le Goff, Philippe Lopes, Konstantinos Gardikis, Carolina Alonso Pozas, Pedro Álvarez, Jamal Ouazzani. Toxicology in Vitro 2020, 66 104869.https://doi.org/10.1016/j.tiv.2020.104869

Draft genome sequence of a Cladosporium species isolated from the mesophotic ascidian Didemnum maculosum.
Anastasia Gioti, Romanos Siaperas, Efstratios Nikolaivits, GĂ©raldine Le Goff, Jamal Ouazzani, Georgios Kotoulas and Evangelos Topakas.
Microbiol Resour Announc 2020, 9:e00311-20. https://doi.org/10.1128/MRA.00311-20.

Inhibition of jasmonate-mediated plant defences by the fungal metabolite higginsianin B. Dallery, J.F., Zimmer, M., Halder, V., Suliman, M., PignĂ©, S., Le Goff, G., Gianniou, D.D., Trougakos, I.P., Ouazzani, J., Gasperini, D., and O’Connell, R.J. 2020. Journal of Experimental Botany, eraa061, https://doi.org/10.1093/jxb/eraa061


2019

Neuroprotective effect of CR-777, the glutathione derivative of withaferin A, obtained through the bioconversion of Withania somnifera (L.) Dunal extract by the fungus Beauveria bassiana.
Chérif Rabhi, Guillaume Arcile, Géraldine Le Goff, Christian Da Costa Noble, Jamal Ouazzani. Molecules 2019, 24(24), 4599; https://doi.org/10.3390/molecules24244599

Impact of the cultivation technique on the production of secondary metabolites by Chrysosporium lobatum TM-237-S5, isolated from the sponge Acanthella cavernosa.
Géraldine Le Goff , Philippe Lopes, Guillaume Arcile, Pinelopi Vlachou, Elsa Van Elslande, Pascal Retailleau, Jean-François Gallard, Michal Weis, Yehuda Benayahu, Nikolas Fokialakis and Jamal Ouazzani. Mar. Drugs 2019, 17, 678; doi:10.3390/md17120678

Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates. Efstratios Nikolaivits, Andreas Agrafiotis, Aikaterini Termentzi, Kyriaki Machera, Géraldine Le Goff, Pedro Álvarez, Suchana Chavanich, Yehuda Benayahu, Jamal Ouazzani, Nikolas Fokialakis and Evangelos Topakas. Mar. Drugs 2019, 17, 564; doi:10.3390/md17100564

Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 inhibits Elastase in Human Fibroblasts. Mamdouh N. Samy, Géraldine Le Goff, Philippe Lopes, Katerina Georgousaki, Sentiljana Gumeni, Celso Almeida, Ignacio GonzĂĄlez, Olga Genilloud, Ioannis Trougakos, Nikolas Fokialakis and Jamal Ouazzani. Molecules 2019, 24, 2239; doi:10.3390/molecules24122239.

Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications. Laure-Anne Peyrat, Nikolaos Tsafantakis, Katerina Georgousaki, Jamal Ouazzani, Olga Genilloud, Ioannis P. Trougakos, Nikolas Fokialakis. Molecules 2019, 24, 1836; doi:10.3390/molecules24091836

Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum. Jean-FĂ©lix Dallery, GĂ©raldine Le Goff, Emilie Adelin, Bogdan I. Iorga, Sandrine PignĂ©, Richard J. O’Connell, Jamal Ouazzani. J. Nat. Prod. 2019. DOI: 10.1021/acs.jnatprod.8b00796

H3K4 trimethylation by CclA regulates pathogenicity and the production of three families of terpenoid secondary metabolites in Colletotrichum higginsianum. Jean-Félix Dallery, Émilie Adelin, Géraldine Le Goff, Sandrine Pigné, Annie Auger, Jamal Ouazzani, Richard J. O’Connell. Molecular Plant Pathology, 2019, DOI: 10.1111/mpp.12795.


2018

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation. Tsakiri, E.N., Gumeni, S., Iliaki, K.K., Benaki, D., Vougas, K., Sykiotis, G.P., Gorgoulis, V.G., Mikros, E., Scorrano, L. and Trougakos, I.P.  Aging cell. Volume 128, Supplement 1, 2018. doi.org/10.1016/j.freeradbiomed.2018.10.316

N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë. Apel, C., Bignon, J., Garcia-Alvarez, M.C., Ciccone, S., Clerc, P., Grondin, I., Girard-Valenciennes, E., Smadja, J., Lopes, P., Frédérich, M., Roussi, F., Meinnel, T., Giglione, C., Litaudon, M. (2018). Fitoterapia, 131, 91-95.

Innovative Approach to Sustainable Marine Invertebrate Chemistry and a Scale-Up Technology for Open Marine Ecosystems. Vlachou, G. Le Goff, C. Alonso, P. A. Álvarez , J-F. Gallard, Nikolas Fokialakis and Jamal Ouazzani; Mar. Drugs, 2018, 16, 0152. doi.org/10.3390/md16050152

Targeting the Pentose Phosphate Pathway: Characterization of a New 6PGL Inhibitor. Anh Tuan Tran, Aude Sadet, Paolo Calligari, Philippe Lopes, Jamal Ouazzani, Matthieu Sollogoub, Emeric Miclet, and Daniel Abergel. Biophysical Journal, 2018, 115, 1–13. DOI : 10.1016/j.bpj.2018.10.027


2017

Sporochartines A-E, A New Family of Natural Products from the Marine Fungus Hypoxylon monticulosum Isolated from a Sphaerocladina Sponge.
Leman-LoubiĂšre, C.; Le Goff, G.; Retailleau, P.; Debitus, C.; Ouazzani, J. Frontiers in Marine Biotechnology, 2017, DOI: 10.3389/fmars.2017.00399

Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast.
Leman-LoubiĂšre, C.; Le Goff, G.; Retailleau, P.; Debitus, C.; Ouazzani, J. (2017). J. Nat .Prod. http://dx.doi.org/10.1021/acs.jnatprod.7b00714 .

Viability-reducing activity of Coryllus avellana L. extracts against human cancer cell lines. GALLEGO A., METON I., BAANANTE I.V., OUAZZANI J., ADELIN E., PALAZON J., BONFILL M., MOYANOA E. Biomedicine & Pharmacotherapy 2017, 89, 565–572.

Total synthesis of the antibiotic 4-hydroxycyclopent-2-en-1-one acrylate derivative EA-2801. LE GOFF G., ADELIN E., ARCILE G., OUAZZANI J. . Tetrahedron Letters, 2017, 58, 2337–2339.

Isolation of the antibiotic methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate EA-2801 from Trichoderma atroviridae.
Emilie Adelin, GĂ©raldine Le Goff, Pascal Retailleau, Mercedes Bonfill and Jamal Ouazzani. The Journal of Antibiotics (2017) 00, 1–4. doi:10.1038/ja.2017.107


2016

Seeking the fountain of youth in the twilight zone.
OUAZZANI J., BENAYAHU Y., TROUGAKOS I.  The Marine Biologist, 2016, 7, 9−11.


2015

Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants.
RABHI C., ARCILE G., CARIEL L., LENOIR C., BIGNON J., WDZIECZAK-BAKALA J., OUAZZANI J. Journal of Medicinal .
J. Med. Food. 2015, doi:10.1089/jmf.2014.0128.

Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis. Audrey Vingadassalon, Florence Lorieux, Maud Juguet, GĂ©raldine Le Goff, Claude Gerbaud, Jean-Luc Pernodet, and Sylvie Lautru. ACS Chem. Biol., 2015, 10, 601–610. DOI : 10.1021/cb500652n

Biohydroxylation of (−)-Ambrox¼, (−)-Sclareol, and (+)- Sclareolide by Whole Cells of Brazilian Marine-Derived Fungi.
Mariana P. Martins, Jamal Ouazzani, Guillaume Arcile, Alex H. Jeller, João P. F. de Lima, Mirna H. R. Seleghim, Ana Lígia L. Oliveira, Hosana M. Debonsi, Tiago Venùncio, Nair S. Yokoya, Mutue T. Fujii, André L. M. Porto. Mar Biotechnol (NY). 2015, 17(2):211-8.


2014

Natural hydrazine-containing compounds: biosynthesis, isolation, biological activities and synthesis.
GĂ©raldine Le Goff and Jamal Ouazzani.
Bioorg Med Chem, 2014. 22, 6529–6544.

Agar-supported cultivation of Halorubrum sp. SSR, and production of halocin C8 on the scale-up prototype Platotex.
Rima Meknaci , Philippe Lopes, Claudine Servy, Jean-Pierre Le Caer, Jean-Pierre Andrieu, Hocine HacĂšne, Jamal Ouazzani.
Extremophiles, 2014, 18(6), 1049-1055.

Bicyclic and tetracyclic diterpenes from a Trichoderma symbiont of Taxus baccata.
Adelin E, Servy C, Martin M-T, Arcile G, I. Iorga B, Pretailleau P, Bonfill M, Ouazzani J.
Phytochemistry, Volume 97, 2014, Pages 55–61.


2013

Total synthesis of geralcin A, a representative of a new family of hydrazine-containing natural products.
GĂ©raldine Le Goff, Emmanuel Roulland, Jamal Ouazzani.
Tetrahedron Letters. 2013, volume 54, issue 39, Pages 5299–5301.

Application of solid-phase extraction to agar-supported fermentation.

GĂ©raldine Le Goff, Emilie Adelin, Sylvie Cortial, Claudine Servy, Jamal Ouazzani.
Bioprocess Biosyst Eng. 2013, 36,1285–1290.

Isolation and Characterization of Unusual Hydrazides from Streptomyces sp. Impact of the Cultivation Support and Extraction Procedure.
Géraldine Le Goff, Marie-ThérÚse Martin, Bogdan I. Iorga, Emilie Adelin, Claudine Servy, Sylvie Cortial, Jamal Ouazzani.
Journal of Natural Products. 2013, volume 76, issue 2,pages 142–149.
New bioactive polyketides isolated from agar-supported fermentation of Phomopsis sp. CMU-LMA, taking advantage of the scale-up device, Platotex.
Emilie Adelin, Marie-ThérÚse Martin, Sylvie Cortial, Pascal Retailleau, Jamal Ouazzani.
Phytochemistry,Volume 93, 2013, Pages 170-175.


2012

Biotransformation of natural compounds: Unexpected thio conjugation of Sch-642305 with 3-mercaptolactate catalyzed by Aspergillus niger ATCC 16404 cells
Emilie Adelin, Marie-ThérÚse Martin, Marie-Françoise Bricot, Sylvie Cortial, Pascal Retailleau, Saisamorn Lumyong, Jamal Ouazzani.
Phytochemistry, Volume 84, 2012, Pages 135-140.

Dehydrogenation, oxidative denitration and ring contraction of N,N-dimethyl-5-nitrouracil by a Bacillus nitroreductase Nfr-A1
Sylvie Cortial, Philippe Chaignon, Didier Sergent, Sophie Dezard, Jamal Ouazzani.
Journal of Molecular Catalysis B: Enzymatic, Volume 76, 2012, Pages 1-8.

Isolation and characterization of α,ÎČ-unsaturated Îł-lactono-hydrazides from Streptomyces sp.
Géraldine Le Goff, Marie-ThérÚse Martin, Claudine Servy, Sylvie Cortial, Philippe Lopes, Anne Bialecki, Jacqueline Smadja, Jamal Ouazzani.
Journal of Natural Products. Volume 75, Issue 5, 2012, Pages 915-919.

Insights into internal dynamics of 6-phosphogluconolactonase from Trypanosoma brucei studied by nuclear magnetic resonance and molecular dynamics.
Calligari PA, Salgado GF, Pelupessy P, Lopes P, Ouazzani J, Bodenhausen G, Abergel D.
Proteins. Volume 80, Issue 4, 2012, Pages1196-1210.


2011

Isolation, structure elucidation and biological activity of metabolites from Sch-642305-producing endophytic fungus Phomopsis sp. CMU-LMA.
Emilie Adelin, Claudine Servy, Sylvie Cortial, HélÚne Lévaique, Marie-ThérÚse Martin, Pascal Retailleau, Géraldine Le Goff, Boonsom Bussaban, Saisamorn Lumyong, Jamal Ouazzani.
Phytochemistry, Volume 72, Issue 18, 2011, Pages 2406-2412.

Microbial decyanation of 1-benzylpyrrolidine-2,5-dicarbonitrile. Mechanistic investigations
Lucimar Pinheiro, Didier Buisson, Sylvie Cortial, Marcel Delaforge, Jamal Ouazzani.
Journal of Molecular Catalysis B: Enzymatic, Volume 68, Issue 2, 2011, Pages 211-215

Biotransformation of natural compounds. Oxido-reduction of Sch-642305 by Aspergillus ochraceus ATCC 1009
Emilie Adelin, Claudine Servy, Sylvie Cortial, HélÚne Lévaique, Jean François Gallard, Marie-ThérÚse Martin, Pascal Retailleau, Boonsom Bussaban, Saisamorn Lumyong, Jamal Ouazzani.
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 8, 2011, Pages 2456-2459.

Monitoring the dynamics of monomer exchange using electrospray mass spectrometry: the case of the dimeric glucosamine-6-phosphate synthase.
Chevreux G, Atmanene C, LopeS P, Ouazzani J, Van Dorsselaer A, Badet B, Badet-Denisot MA, Sanglier-Cianférani S.
J Am Soc Mass Spectrom. Volume 22, Issue 3, 2011, Pages 431-439.

Platotex: an innovative and fully automated device for cell growth scale-up of agar-supported solid-state fermentation.
Adelin E, Slimani N, Cortial S, Schmitz-Alfonso I, Ouazzani J.
J Ind Microbiol Biotechnol. Volume 38, Issue 2, 2011, Pages 299-305.


2010

NADH oxidase activity of Bacillus subtilis nitroreductase NfrA1: insight into its biological role.
Cortial S, Chaignon P, Iorga BI, Aymerich S, Truan G, Gueguen-Chaignon V, Meyer P, Moréra S, Ouazzani J.
FEBS Lett. Volume 584, Issue 18, 2010, Pages 3916-3922.

Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
Leverrier A, Martin MT, Servy C, Ouazzani J, Retailleau P, Awang K, Mukhtar MR, Guéritte F, Litaudon M. Journal of Natural Products. Volume 73, Issue 6, 2010, 1121-1125.