Eight polyketide compounds were isolated from the cultivation broth of Phomopsis sp. CMU-LMA. This opens perspectives for a multidisciplinary approach including bioassays, chemo-diversification and production of the target enzyme. These parts of the project were achieved successfully.
We have previously published a hypothetic biosynthesis based on the structure of the isolated intermediates. This encourage us to established a collaboration with the group of Prof. Russell J. Cox (director of the “institut für Organische Chemie”, Hanover, Germany) to investigate for the first time the biosynthetic gene cluster of the SCH family of compounds.
Partner: Prof. Russell J. Cox, Leibniz Universität Hannover, Institute of Organic Chemistry/ BMWZ, Hannover, Germany