N2MAC is dedicated to bioactive compounds isolated from microorganisms. The project explores an almost virgin topic related to an under-exploited family of natural compounds. The starting intriguing observations were the extreme rarity of N-N bond containing natural compounds (N2NP). Among 250.000 natural compounds known, less than 200 contain an N-N bond and more than 60% of these compounds were isolated from actinomycetes, in particular from the Streptomyces genus, our target organism.
The objectives are:
Identifying gene clusters involved in the biosynthesis of N2NP.
Mastering and improving the production conditions of N2NP by Streptomyces.
Focusing on geralcins, an original family of N2NP discovered by the coordinator laboratory. Total synthesis of geralcin A have been published and the gene cluster involved in the biosynthesis of geralcins is studying.
Implementation of an original “chemo-mimetic biosynthesis” concept.
Evaluation of biological role and activities of N2MAC molecules.
N2MAC brings together teams used to multidisciplinarity and hosts expertise and technical resources requested to achieve the project objectives.