THE PILOT UNIT OF ICSN - EXCELLENCE IN THE FIELD OF BIOACTIVE MICROBIAL SECONDARY METABOLITES
N2MAC is dedicated to bioactive compounds isolated from microorganisms. The project explores an almost virgin topic related to an under-exploited family of natural compounds. The starting intriguing observations were the extreme rarity of N-N bond containing natural compounds (N2NP). Among 250.000 natural compounds known, less than 200 contain an N-N bond and more than 60% of these compounds were isolated from actinomycetes, in particular from the Streptomyces genus, our target organism.
The objectives are:
  • Identifying gene clusters involved in the biosynthesis of N2NP.
  • Mastering and improving the production conditions of N2NP by Streptomyces.
  • Focusing on geralcins, an original family of N2NP discovered by the coordinator laboratory. Total synthesis of geralcin A have been published and the gene cluster involved in the biosynthesis of geralcins is studying.
  • Implementation of an original “chemo-mimetic biosynthesis” concept.
  • Evaluation of biological role and activities of N2MAC molecules.
N2MAC brings together teams used to multidisciplinarity and hosts expertise and technical resources requested to achieve the project objectives.